ODN 2216 Biotin - TLR9 Agonist

Biotin labeled CpG oligonucleotide - Human TLR9 ligand

CpG  ODNs are synthetic oligonucleotides that contain unmethylated CpG  dinucleotides in particular sequence contexts (CpG motifs).

These CpG  motifs are present at a 20-fold greater frequency in bacterial DNA  compared to mammalian DNA. They have been shown to induce a coordinated  set of immune responses based on the activation of immune cells  primarily involved in the recognition of these molecules.

ODN 2216 Biotin is a A-class CpG ODN with a preference for human TLR9.

ODN 2216 Biotin can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.