LTA-SA - TLR2 Agonist

LTA from S. aureus

ABOUT

Lipoteichoic acid from S. aureus

Lipoteichoic acid (LTA) is a major immunostimulatory component of Gram-positive bacteria. Like LPS, LTA is an amphiphile formed by a hydrophilic polyphosphate polymer linked to a neutral glycolipid.

LTA stimulates immune cells through TLR2 to produce TNF-α and other inflammatory cytokines. Recognition of LTA involves also LPS-binding protein (LBP) and CD14.

InvivoGen provides LTA purified from S. aureus (LTA-SA) with the EndoFit™ grade (<0.001 EU/μg).

All products are for research use only, and not for human or veterinary use.

SPECIFICATIONS

Specifications

Source
Staphylococcus aureus
Target

TLR2

Working concentration

 1 ng -1 μg/ml for cellular assays

Reconstitution buffer
Endotoxin-free water (provided)
Endotoxin

< 0.001 EU/μg (measurement by kinetic chromogenic LAL assay)

Tested applications

Cellular assays

Quality control

Each lot is functionally tested and validated using HEK-Blue™ hTLR2 Cells.

CONTENTS

Contents

  • Product: 
    Purified LTA-SA
  • Cat code: 
    tlrl-pslta
  • Quantity: 
    5 mg
Includes:

10 ml of endotoxin-free water

Shipping & Storage

  • Shipping method:  Room temperature
  • Storage:

    • Upon receipt, store product at -20 °C
    Stability: The reconstituted product is stable up to 6 months at -20 °C.

    Caution:

    • Avoid repeated freeze-thaw cycles

DOCUMENTS

Documents

Purified LTA-SA

Technical Data Sheet

Safety Data Sheet

Certificate of analysis

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CUSTOMER SERVICE & TECHNICAL SUPPORT

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