Anti-hIL-1α-IgG
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Cat.code:
mabg-hil1a-3
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ABOUT
Neutralizing monoclonal antibody against human interleukin 1 alpha
Anti-hIL-1α-IgG (clone 7D4) is a monoclonal antibody (mAb) specific for human interleukin 1 alpha (hIL-1α). It is produced in hybridomas and purified by affinity chromatography. This antibody has been selected for its ability to efficiently neutralize the biological activity of hIL-1α.
IL-1α is a pro-inflammatory cytokine that plays a central role in the regulation of immune responses and inflammation [1].
Key features:
- A potent and specific neutralizing mAb against hIL-1α
- Provided azide-free
- No cross-reactivity with human IL-1β, murine IL-1α, or murine IL-1β
- Each lot is functionally tested
Reference:
1. Dinarello C., 2018. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 281(1): 8–27.
All products are for internal research use only, and not for human or veterinary use.
SPECIFICATIONS
Specifications
Blocking and Neutralizing
0.2 µm filtered solution in sodium phosphate buffer with glycine, saccharose and stabilizing agents
Blocking, Neutralization
The antibody has been validated for neutralization using cellular assays. The absence of bacterial contamination (e.g. endotoxins and lipoproteins) has been confirmed using HEK-Blue™ TLR2 and HEK-Blue™ TLR4 cells.
CONTENTS
Contents
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Product:Anti-hIL-1α-IgG
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Cat code:mabg-hil1a-3
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Quantity:3 x 100 µg
Shipping & Storage
- Shipping method: Room temperature
- -20°C
- Avoid repeated freeze-thaw cycles
Storage:
Caution:
Details
Interleukin-1 alpha (IL-1α) is a secreted pro-inflammatory cytokine produced primarily by activated macrophages [1]. IL-1α is synthesized as a pro‑cytokine, which is enzymatically cleaved into the mature secreted form by calpain, a calcium-dependent protease [2]. In contrast to other cytokines, both the precursor and mature forms of IL-1α are biologically active.
IL-1α plays a central role in the regulation of immune responses and inflammation. IL-1α binds to the interleukin-1 receptor, leading to the activation of NF-κB signaling and the JNK and p38 mitogen-activated protein kinase pathways, which induce the expression of inflammatory cytokines and chemokines, such as IL-6 and IL-8 [3].
1. Dinarello C., 2018. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 281(1): 8-27.
2. Sims J. & Smith D., 2010. The IL-1 family: regulators of immunity. Nat Rev Immunol. 10(2):89-102.
3. Weber A. et al., 2010. Interleukin-1 (IL-1) pathway. Sci Signal. 3(105):cm1.
DOCUMENTS
Documents
Technical Data Sheet
Safety Data Sheet
Validation Data Sheet
Certificate of analysis
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