26S proteasome inhibitor

26S proteasome inhibition by MG-132

MG-132 is a peptide aldehyde (Z-Leu-Leu-Leu-al) that selectively blocks the proteolytic activity of the 26S proteasome. The 26S proteasome is a large protease complex that degrades ubiquitinated proteins into smaller peptides. It plays a central role in the regulation of proteins that control cell-cycle progression and apoptosis.

More details

Mode of action:

MG-132 reduces the degradation of ubiquitin-conjugated proteins in mammalian cells by the 26S proteasome. This potent inhibitor is used as a tool for disrupting the proteasome-regulated degradation of intracellular proteins, such as IκB. Inhibition of IκB proteasomal degradation by MG-132 leads to the suppression of NF-κB activation [1].
Of note, studies suggest that inhibition of the 26S proteasome by MG-132 can induce autophagy by stabilizing Atg protein levels [2].

Key features:

A potent inhibitor of the 26S proteasome
An autophagy inducer
InvitroFit™ grade: each lot is functionally tested

References

1. Lee DH, Goldberg A.L., 1998. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 8(10):397-403.
2. Ge PF. et al., 2009. Inhibition of autophagy induced by proteasome inhibition increases cell death in human SHG-44 glioma cells. Acta Pharmacol Sin. 30(7):1046-52.

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